obsolete_cleft palate: ['Congenital fissure of the soft and/or hard palate, due to faulty fusion.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
472983 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
371 |
4. Check minimum number of eventsNone |
371 |
5. Include endpointsNone |
371 |
6. Filter based on genotype QC (FinnGen only) |
361 |
Control definitions (FinnGen only)
Control exclude
Q17_CLEFT_LIP_CLEFT_PALATE
Extra metadata
First used in FinnGen datafreeze
DF7
Similar endpoints
↥List of similar endpoints to
Cleft palate
based on the number of shared cases.
Similar with more cases:
- Cleft lip, lip and palate or palate
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5369 | 3001 | 2360 |
| Only index persons | 4471 | 2522 | 1949 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.07 |
| Only index persons | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 1.83 | 1.71 | 1.86 |
| Only index persons | 1.89 | 1.81 | 1.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 361 | 250 | 111 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.06 |
| Median age at first event (years) | 2.82 | 2.15 | 4.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CLEFT_PALATE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CLEFT_PALATE | 1.685 [1.24, 2.3] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1196 males with Q17_CLEFT_PALATE died.
Mortality risk
Mortality risk for people of age
years, who have Q17_CLEFT_PALATE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.31% |
| 5 | No data | 2.108% |
| 10 | No data | 4.96% |
| 15 | No data | 9.258% |
| 20 | No data | 15.23% |
Relationships between endpoints
↥Index endpoint: Q17_CLEFT_PALATE – Cleft palate
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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