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Caries in Clefts patients

Endpoint Browser PheWeb

Q17_CLEFT_AND_CARIES

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • Q17_CLEFT_LIP_CLEFT_PALATE
576

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K02
  • Hospital discharge: ICD-10 — K02
  • Hospital discharge: ICD-9 — 5210A
  • Hospital discharge: ICD-8 — 52100
  • Cause of death: ICD-10 — K02
  • Cause of death: ICD-9 — 5210A
  • Cause of death: ICD-8 — 52100

3 out of 7 registries used, show all original rules.

327

4. Check minimum number of events

None

327

5. Include endpoints

None

327

6. Filter based on genotype QC (FinnGen only)

314

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4252 2191 2056
Only index persons 3920 2029 1891
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 24.85 25.22 24.43
Only index persons 26.57 26.87 26.26

-FinnGen-

Key figures

All Female Male
Number of individuals 314 202 112
Unadjusted period prevalence (%) 0.07 0.08 0.06
Median age at first event (years) 37.35 37.50 37.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint Q17_CLEFT_AND_CARIES and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
Q17_CLEFT_AND_CARIES 1.835 [1.26, 2.67] 0.002
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1798 males with Q17_CLEFT_AND_CARIES died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CLEFT_AND_CARIES.

N-year risk Females Males
1 No data 0.411%
5 No data 2.223%
10 No data 5.802%
15 No data 10.596%
20 No data 17.778%

Relationships between endpoints

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Index endpoint: Q17_CLEFT_AND_CARIES – Caries in Clefts patients

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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