Neonatal jaundice from other and unspecified causes

P16_NEONTAL_JAUND_OTH_UNSP_CAUSES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 P59
  • Cause of death: ICD-10 P59

2 out of 7 registries used, show all original rules.

469

4. Check minimum number of events

None

469

5. Include endpoints

None

469

6. Filter based on genotype QC (FinnGen only)

433

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4
Parent code in ICD-10 P[5-6]
Name in latin Icterus neonatalis ex causis aliis et non specificatis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 54258 22632 31624
Only index persons 20837 8616 12221
Unadjusted period prevalence (%)
Whole population 0.79 0.65 0.88
Only index persons 0.40 0.32 0.47
Median age at first event (years)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01

-FinnGen-

Key figures

All Female Male
Number of individuals 433 226 207
Unadjusted period prevalence (%) 0.10 0.09 0.10
Median age at first event (years) 0.01 0.01 0.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint P16_NEONTAL_JAUND_OTH_UNSP_CAUSES and mortality.

Females

Parameter HR [95% CI] p-value
P16_NEONTAL_JAUND_OTH_UNSP_CAUSES 0.886 [0.66, 1.18] 0.414
Birth year 0.992 [0.98, 1.0] 0.071

During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 21667 females with P16_NEONTAL_JAUND_OTH_UNSP_CAUSES died.

Males

Parameter HR [95% CI] p-value
P16_NEONTAL_JAUND_OTH_UNSP_CAUSES 1.62 [1.3, 2.02] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 30217 males with P16_NEONTAL_JAUND_OTH_UNSP_CAUSES died.

Mortality risk

Mortality risk for people of age

years, who have P16_NEONTAL_JAUND_OTH_UNSP_CAUSES.

N-year risk Females Males
1 0.074% 0.285%
5 0.496% 1.797%
10 1.153% 4.374%
15 2.246% 8.121%
20 4.072% 13.464%

Relationships between endpoints

Index endpoint: P16_NEONTAL_JAUND_OTH_UNSP_CAUSES – Neonatal jaundice from other and unspecified causes

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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