Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium

O15_OTHER_MATERN_DIS_ELSEWHERE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O99
  • Cause of death: ICD-10 O99

2 out of 7 registries used, show all original rules.

16923

4. Check minimum number of events

None

16923

5. Include endpoints

None

16923

6. Filter based on genotype QC (FinnGen only)

16063

Control definitions (FinnGen only)

Control exclude O15_OBSTET_NAS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O94-O99
Name in latin Alii morbi materni alibi classificabiles sed complicantes graviditatem, partum et puerperium

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 125535 125535 -
Only index persons 124618 124618 -
Unadjusted period prevalence (%)
Whole population 3.60 3.60 -
Only index persons 4.58 4.58 -
Median age at first event (years)
Whole population - 30.77 -
Only index persons - 30.77 -

-FinnGen-

Key figures

All Female Male
Number of individuals 16063 16063 -
Unadjusted period prevalence (%) 6.31 6.31 -
Median age at first event (years) 31.32 31.32 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_OTHER_MATERN_DIS_ELSEWHERE and mortality.

Females

Parameter HR [95% CI] p-value
O15_OTHER_MATERN_DIS_ELSEWHERE 0.875 [0.76, 1.01] 0.074
Birth year 0.997 [0.99, 1.0] 0.432

During the follow-up period (1.1.1998 — 31.12.2019), 620 out of 107138 females with O15_OTHER_MATERN_DIS_ELSEWHERE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_OTHER_MATERN_DIS_ELSEWHERE.

N-year risk Females Males
1 0.09% No data
5 0.468% No data
10 1.288% No data
15 2.491% No data
20 4.586% No data

Relationships between endpoints

Index endpoint: O15_OTHER_MATERN_DIS_ELSEWHERE – Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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