prostate disease: A disease involving the prostate gland.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly males |
207946 |
2. Check conditionsNone |
207946 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1192 |
4. Check minimum number of eventsNone |
1192 |
5. Include endpointsNone |
1192 |
6. Filter based on genotype QC (FinnGen only) |
1168 |
Control definitions (FinnGen only)
Control exclude
N14_MALEGEN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N40-N51
Name in latin
Aliae morbositates prostatae
Other disorders of prostate
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10209 | - | 10209 |
| Only index persons | 8368 | - | 8368 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.29 | - | 0.29 |
| Only index persons | 0.32 | - | 0.32 |
| Median age at first event (years) | |||
| Whole population | - | - | 67.24 |
| Only index persons | - | - | 65.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1168 | - | 1168 |
| Unadjusted period prevalence (%) | 0.59 | - | 0.59 |
| Median age at first event (years) | 66.21 | - | 66.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_PROSTAOTH and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_PROSTAOTH | 1.179 [1.08, 1.29] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 2797 out of 7873 males with N14_PROSTAOTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_PROSTAOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.215% |
| 5 | No data | 1.531% |
| 10 | No data | 3.6% |
| 15 | No data | 6.648% |
| 20 | No data | 11.126% |
Relationships between endpoints
↥Index endpoint: N14_PROSTAOTH – Other disorders of prostate
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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