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Postmenopausal atrophic vaginitis

DOID EFO Endpoint Browser PheWeb

N14_POSTMENATRVAG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — N95.2
  • Hospital discharge: ICD-10 — N95.2
  • Hospital discharge: ICD-9 — 6273
  • Hospital discharge: ICD-8 — 62990
  • Cause of death: ICD-10 — N95.2
  • Cause of death: ICD-9 — 6273
  • Cause of death: ICD-8 — 62990

3 out of 7 registries used, show all original rules.

9777

4. Check minimum number of events

None

9777

5. Include endpoints

None

9777

6. Filter based on genotype QC (FinnGen only)

9484

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF10
Parent code in ICD-10 N95
Name in latin Colpitis postmenopausalis atrophica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 49654 49654 -
Only index persons 48311 48311 -
Unadjusted period prevalence (%)
Whole population 1.42 1.42 -
Only index persons 1.78 1.78 -
Median age at first event (years)
Whole population - 66.70 -
Only index persons - 66.54 -

-FinnGen-

Key figures

All Female Male
Number of individuals 9484 9484 -
Unadjusted period prevalence (%) 3.72 3.72 -
Median age at first event (years) 65.64 65.64 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_POSTMENATRVAG and mortality.

Females

Parameter HR [95% CI] p-value
N14_POSTMENATRVAG 1.118 [1.02, 1.23] 0.023
Birth year 0.996 [0.99, 1.0] 0.315

During the follow-up period (1.1.1998 — 31.12.2019), 3779 out of 19347 females with N14_POSTMENATRVAG died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_POSTMENATRVAG.

N-year risk Females Males
1 0.12% No data
5 0.718% No data
10 1.72% No data
15 3.284% No data
20 5.822% No data

Relationships between endpoints

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Index endpoint: N14_POSTMENATRVAG – Postmenopausal atrophic vaginitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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