phimosis: A condition in which there is constriction in the tip of the foreskin resulting in inability to fully retract the foreskin over the glans penis. Causes include balanoposthitis, balanitis xerotica obliterans, and untreated diabetes.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly males |
207946 |
2. Check conditionsNone |
207946 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8924 |
4. Check minimum number of eventsNone |
8924 |
5. Include endpointsNone |
8924 |
6. Filter based on genotype QC (FinnGen only) |
8655 |
Control definitions (FinnGen only)
Control exclude
N14_MALEGEN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N40-N51
Name in latin
Praeputium redundans, phimosis sive paraphimosis
Redundant prepuce, phimosis and paraphimosis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 122230 | - | 122230 |
| Only index persons | 113219 | - | 113219 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.42 | - | 3.42 |
| Only index persons | 4.32 | - | 4.32 |
| Median age at first event (years) | |||
| Whole population | - | - | 15.09 |
| Only index persons | - | - | 15.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8655 | - | 8655 |
| Unadjusted period prevalence (%) | 4.35 | - | 4.35 |
| Median age at first event (years) | 29.03 | - | 29.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_PHIMOSIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_PHIMOSIS | 1.419 [1.25, 1.61] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 6047 out of 65740 males with N14_PHIMOSIS died.
Mortality risk
Mortality risk for people of age
years, who have N14_PHIMOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.341% |
| 5 | No data | 1.94% |
| 10 | No data | 4.629% |
| 15 | No data | 8.563% |
| 20 | No data | 14.111% |
Relationships between endpoints
↥Index endpoint: N14_PHIMOSIS – Redundant prepuce, phimosis and paraphimosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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