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Ovarian cyst

DOID EFO Endpoint Browser PheWeb

N14_OVARYCYST

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N83.0, N83.1, N83.2
  • Hospital discharge: ICD-9 — 620[0-2]
  • Hospital discharge: ICD-8 — 2191|6152
  • Cause of death: ICD-10 — N83.0, N83.1, N83.2
  • Cause of death: ICD-9 — 620[0-2]
  • Cause of death: ICD-8 — 2191|6152

2 out of 7 registries used, show all original rules.

26539

4. Check minimum number of events

None

26539

5. Include endpoints

None

26539

6. Filter based on genotype QC (FinnGen only)

25564

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 178516 178516 -
Only index persons 172360 172360 -
Unadjusted period prevalence (%)
Whole population 5.11 5.11 -
Only index persons 6.34 6.34 -
Median age at first event (years)
Whole population - 41.92 -
Only index persons - 41.69 -

-FinnGen-

Key figures

All Female Male
Number of individuals 25564 25564 -
Unadjusted period prevalence (%) 10.04 10.04 -
Median age at first event (years) 42.49 42.49 -

-FinRegistry-

Age distribution of first events

01020304050607080900k5k10k15k20k25k30k35k40k45kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0k4.5k5.0k5.5k6.0k6.5kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220k2k4k6k8k10k12k14k16k18k20k22k24k26k28kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230.0k0.5k1.0k1.5k2.0k2.5k3.0k3.5k4.0kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000246810121416AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000246810121416182022AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint N14_OVARYCYST and mortality.

Females

Parameter HR [95% CI] p-value
N14_OVARYCYST 1.02 [0.94, 1.11] 0.645
Birth year 0.997 [0.99, 1.01] 0.508

During the follow-up period (1.1.1998 — 31.12.2019), 8211 out of 122743 females with N14_OVARYCYST died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_OVARYCYST.

N-year risk Females Males
1 0.07% No data
5 0.612% No data
10 1.638% No data
15 2.965% No data
20 5.192% No data

Relationships between endpoints

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Index endpoint: N14_OVARYCYST – Ovarian cyst

GWS hits: 10

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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