Irregular menses

N14_MENSIRREG

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N91, N92.1, N92.5, N92.6
  • Hospital discharge: ICD-9 6264A
  • Hospital discharge: ICD-8 6265
  • Cause of death: ICD-10 N91, N92.1, N92.5, N92.6
  • Cause of death: ICD-9 6264A
  • Cause of death: ICD-8 6265

2 out of 7 registries used, show all original rules.

22757

4. Check minimum number of events

None

22757

5. Include endpoints

None

22757

6. Filter based on genotype QC (FinnGen only)

21784

Control definitions (FinnGen only)

Control exclude E4_PCOS_CONCORTIUM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6
Parent code in ICD-10 N80-N98
Name in latin Menstruatio abundans, frequens et irregularis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 156837 156837 -
Only index persons 152088 152088 -
Unadjusted period prevalence (%)
Whole population 4.49 4.49 -
Only index persons 5.59 5.59 -
Median age at first event (years)
Whole population - 40.30 -
Only index persons - 40.09 -

-FinnGen-

Key figures

All Female Male
Number of individuals 21784 21784 -
Unadjusted period prevalence (%) 8.56 8.56 -
Median age at first event (years) 40.74 40.74 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_MENSIRREG and mortality.

Females

Parameter HR [95% CI] p-value
N14_MENSIRREG 1.224 [1.12, 1.34] < 0.001
Birth year 0.997 [0.99, 1.0] 0.456

During the follow-up period (1.1.1998 — 31.12.2019), 3729 out of 113292 females with N14_MENSIRREG died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_MENSIRREG.

N-year risk Females Males
1 0.107% No data
5 0.721% No data
10 1.952% No data
15 3.719% No data
20 6.491% No data

Relationships between endpoints

Index endpoint: N14_MENSIRREG – Irregular menses

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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