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Other menopausal disorders

DOID EFO Endpoint Browser PheWeb

N14_MENOPAUSOT

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — N95.1, N95.3, N95.8, N95.9
  • Hospital discharge: ICD-10 — N95.1, N95.3, N95.8, N95.9
  • Hospital discharge: ICD-9 — 6272|627[4-9]
  • Hospital discharge: ICD-8 — 627
  • Cause of death: ICD-10 — N95.1, N95.3, N95.8, N95.9
  • Cause of death: ICD-9 — 6272|627[4-9]
  • Cause of death: ICD-8 — 627

3 out of 7 registries used, show all original rules.

20819

4. Check minimum number of events

None

20819

5. Include endpoints

None

20819

6. Filter based on genotype QC (FinnGen only)

20131

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF10

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 106654 106654 -
Only index persons 104638 104638 -
Unadjusted period prevalence (%)
Whole population 3.05 3.05 -
Only index persons 3.85 3.85 -
Median age at first event (years)
Whole population - 54.74 -
Only index persons - 54.78 -

-FinnGen-

Key figures

All Female Male
Number of individuals 20131 20131 -
Unadjusted period prevalence (%) 7.91 7.91 -
Median age at first event (years) 55.18 55.18 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_MENOPAUSOT and mortality.

Females

Parameter HR [95% CI] p-value
N14_MENOPAUSOT 1.112 [0.98, 1.26] 0.088
Birth year 0.994 [0.99, 1.0] 0.147

During the follow-up period (1.1.1998 — 31.12.2019), 2016 out of 38463 females with N14_MENOPAUSOT died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_MENOPAUSOT.

N-year risk Females Males
1 0.086% No data
5 0.576% No data
10 1.551% No data
15 2.756% No data
20 5.204% No data

Relationships between endpoints

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Index endpoint: N14_MENOPAUSOT – Other menopausal disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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