Disorders of male genital organs in diseases classified elsewhere

N14_MALEGENINOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only males

207946

2. Check conditions

None

207946

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N51*
  • Cause of death: ICD-10 N51*

2 out of 7 registries used, show all original rules.

201

4. Check minimum number of events

None

201

5. Include endpoints

None

201

6. Filter based on genotype QC (FinnGen only)

192

Control definitions (FinnGen only)

Control exclude N14_MALEGEN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2125 - 2125
Only index persons 2038 - 2038
Unadjusted period prevalence (%)
Whole population 0.06 - 0.06
Only index persons 0.08 - 0.08
Median age at first event (years)
Whole population - - 34.45
Only index persons - - 34.35

-FinnGen-

Key figures

All Female Male
Number of individuals 192 - 192
Unadjusted period prevalence (%) 0.10 - 0.10
Median age at first event (years) 47.05 - 47.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_MALEGENINOTH and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
N14_MALEGENINOTH 1.305 [1.07, 1.59] 0.008
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 1765 males with N14_MALEGENINOTH died.

Mortality risk

Mortality risk for people of age

years, who have N14_MALEGENINOTH.

N-year risk Females Males
1 No data 0.236%
5 No data 1.558%
10 No data 3.758%
15 No data 7.027%
20 No data 11.796%

Relationships between endpoints

Index endpoint: N14_MALEGENINOTH – Disorders of male genital organs in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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