Inflammatory disorders of male genital organs, not elsewhere classified

N14_INFLAMALEGEN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only males

207946

2. Check conditions

None

207946

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N49
  • Hospital discharge: ICD-9 6080|6084
  • Hospital discharge: ICD-8 607[4-5]
  • Cause of death: ICD-10 N49
  • Cause of death: ICD-9 6080|6084
  • Cause of death: ICD-8 607[4-5]

2 out of 7 registries used, show all original rules.

448

4. Check minimum number of events

None

448

5. Include endpoints

None

448

6. Filter based on genotype QC (FinnGen only)

437

Control definitions (FinnGen only)

Control exclude N14_MALEGEN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N40-N51
Name in latin Morbositates inflammatoriae organorum genitalium masculinorum non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4288 - 4288
Only index persons 3668 - 3668
Unadjusted period prevalence (%)
Whole population 0.12 - 0.12
Only index persons 0.14 - 0.14
Median age at first event (years)
Whole population - - 48.29
Only index persons - - 45.88

-FinnGen-

Key figures

All Female Male
Number of individuals 437 - 437
Unadjusted period prevalence (%) 0.22 - 0.22
Median age at first event (years) 53.78 - 53.78

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_INFLAMALEGEN and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
N14_INFLAMALEGEN 2.512 [2.08, 3.03] < 0.001
Birth year 0.99 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 722 out of 2965 males with N14_INFLAMALEGEN died.

Mortality risk

Mortality risk for people of age

years, who have N14_INFLAMALEGEN.

N-year risk Females Males
1 No data 0.608%
5 No data 3.211%
10 No data 7.611%
15 No data 14.331%
20 No data 23.47%

Relationships between endpoints

Index endpoint: N14_INFLAMALEGEN – Inflammatory disorders of male genital organs, not elsewhere classified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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