erectile dysfunction: Persistent or recurrent inability to achieve or to maintain an erection during sexual activity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly males |
207946 |
2. Check conditionsNone |
207946 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1771 |
4. Check minimum number of eventsNone |
1771 |
5. Include endpointsNone |
1771 |
6. Filter based on genotype QC (FinnGen only) |
1698 |
Control definitions (FinnGen only)
Control exclude
N14_MALEGEN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N48
Name in latin
Impotentia organica
Impotence
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10197 | - | 10197 |
| Only index persons | 9386 | - | 9386 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | - | 0.28 |
| Only index persons | 0.36 | - | 0.36 |
| Median age at first event (years) | |||
| Whole population | - | - | 57.03 |
| Only index persons | - | - | 56.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1698 | - | 1698 |
| Unadjusted period prevalence (%) | 0.85 | - | 0.85 |
| Median age at first event (years) | 59.52 | - | 59.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_IMPOTENCE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_IMPOTENCE | 1.27 [1.16, 1.39] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.084 |
During the follow-up period (1.1.1998 — 31.12.2019), 1515 out of 7025 males with N14_IMPOTENCE died.
Mortality risk
Mortality risk for people of age
years, who have N14_IMPOTENCE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.285% |
| 5 | No data | 1.865% |
| 10 | No data | 4.533% |
| 15 | No data | 8.42% |
| 20 | No data | 13.963% |
Relationships between endpoints
↥Index endpoint: N14_IMPOTENCE – Impotence
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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