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Female genital prolapse

DOID EFO Endpoint Browser PheWeb

N14_FEMGENPROL

male reproductive organ cancer: A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N81
  • Hospital discharge: ICD-9 — 618
  • Hospital discharge: ICD-8 — 623
  • Hospital discharge: excluded ICD-9 — 6185
  • Cause of death: ICD-10 — N81
  • Cause of death: ICD-9 — 618
  • Cause of death: ICD-8 — 623
  • Cause of death: excluded ICD-9 — 6185

2 out of 7 registries used, show all original rules.

21295

4. Check minimum number of events

None

21295

5. Include endpoints

None

21295

6. Filter based on genotype QC (FinnGen only)

20634

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N80-N98
Name in latin Prolapsus organorum genitalium femininorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 179769 179769 -
Only index persons 152491 152491 -
Unadjusted period prevalence (%)
Whole population 5.15 5.15 -
Only index persons 5.61 5.61 -
Median age at first event (years)
Whole population - 60.48 -
Only index persons - 59.32 -

-FinnGen-

Key figures

All Female Male
Number of individuals 20634 20634 -
Unadjusted period prevalence (%) 8.10 8.10 -
Median age at first event (years) 57.37 57.37 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_FEMGENPROL and mortality.

Females

Parameter HR [95% CI] p-value
N14_FEMGENPROL 0.83 [0.77, 0.89] < 0.001
Birth year 0.999 [0.99, 1.01] 0.81

During the follow-up period (1.1.1998 — 31.12.2019), 17689 out of 105647 females with N14_FEMGENPROL died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FEMGENPROL.

N-year risk Females Males
1 0.067% No data
5 0.444% No data
10 1.239% No data
15 2.381% No data
20 4.283% No data

Relationships between endpoints

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Index endpoint: N14_FEMGENPROL – Female genital prolapse

GWS hits: 21

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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