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Calculus of lower urinary tract

DOID EFO Endpoint Browser PheWeb

N14_CALCULOWER

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N21
  • Hospital discharge: ICD-9 — 594
  • Hospital discharge: ICD-8 — 594
  • Cause of death: ICD-10 — N21
  • Cause of death: ICD-9 — 594
  • Cause of death: ICD-8 — 594

2 out of 7 registries used, show all original rules.

1781

4. Check minimum number of events

None

1781

5. Include endpoints

None

1781

6. Filter based on genotype QC (FinnGen only)

1681

Control definitions (FinnGen only)

Control exclude N14_UROLITHIASIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N20-N23
Name in latin Urolithiasis viarum urinariarum inferiorum

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15015 2873 11922
Only index persons 12181 2461 9720
Unadjusted period prevalence (%)
Whole population 0.28 0.08 0.33
Only index persons 0.31 0.09 0.37
Median age at first event (years)
Whole population 65.15 55.17 67.47
Only index persons 63.53 52.20 66.39

-FinnGen-

Key figures

All Female Male
Number of individuals 1681 295 1386
Unadjusted period prevalence (%) 0.59 0.12 0.70
Median age at first event (years) 64.85 50.85 67.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_CALCULOWER and mortality.

Females

Parameter HR [95% CI] p-value
N14_CALCULOWER 1.812 [1.52, 2.16] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 398 out of 1853 females with N14_CALCULOWER died.

Males

Parameter HR [95% CI] p-value
N14_CALCULOWER 1.241 [1.11, 1.38] < 0.001
Birth year 0.98 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2580 out of 8052 males with N14_CALCULOWER died.

Mortality risk

Mortality risk for people of age

years, who have N14_CALCULOWER.

N-year risk Females Males
1 0.133% 0.16%
5 0.89% 1.114%
10 2.155% 2.884%
15 4.038% 5.312%
20 6.862% 8.746%

Relationships between endpoints

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Index endpoint: N14_CALCULOWER – Calculus of lower urinary tract

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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