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Calculus of kidney and ureter

DOID EFO Endpoint Browser PheWeb

N14_CALCUKIDUR

nephrolithiasis: The presence of a calculus in the pelvis of the kidney; this is most often composed of mineral salts and proteins.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N20
  • Hospital discharge: ICD-9 — 592
  • Hospital discharge: ICD-8 — 592
  • Cause of death: ICD-10 — N20
  • Cause of death: ICD-9 — 592
  • Cause of death: ICD-8 — 592

2 out of 7 registries used, show all original rules.

12361

4. Check minimum number of events

None

12361

5. Include endpoints

None

12361

6. Filter based on genotype QC (FinnGen only)

11650

Control definitions (FinnGen only)

Control exclude N14_UROLITHIASIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N20-N23
Name in latin Nephrolithiasis et/sive ureterolithiasis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 106516 34091 71098
Only index persons 92532 31030 61502
Unadjusted period prevalence (%)
Whole population 1.66 0.98 1.99
Only index persons 1.94 1.14 2.35
Median age at first event (years)
Whole population 49.99 48.35 50.79
Only index persons 48.66 46.79 49.60

-FinnGen-

Key figures

All Female Male
Number of individuals 11650 4075 7575
Unadjusted period prevalence (%) 3.03 1.60 3.80
Median age at first event (years) 50.76 45.93 53.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_CALCUKIDUR and mortality.

Females

Parameter HR [95% CI] p-value
N14_CALCUKIDUR 1.155 [1.05, 1.27] 0.004
Birth year 0.993 [0.98, 1.0] 0.087

During the follow-up period (1.1.1998 — 31.12.2019), 2310 out of 19947 females with N14_CALCUKIDUR died.

Males

Parameter HR [95% CI] p-value
N14_CALCUKIDUR 0.892 [0.82, 0.97] 0.005
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 5482 out of 39861 males with N14_CALCUKIDUR died.

Mortality risk

Mortality risk for people of age

years, who have N14_CALCUKIDUR.

N-year risk Females Males
1 0.105% 0.173%
5 0.632% 1.075%
10 1.711% 2.715%
15 3.186% 4.916%
20 5.476% 8.219%

Relationships between endpoints

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Index endpoint: N14_CALCUKIDUR – Calculus of kidney and ureter

GWS hits: 19

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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