osteitis deformans: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
155 |
4. Check minimum number of eventsNone |
155 |
5. Include endpointsNone |
155 |
6. Filter based on genotype QC (FinnGen only) |
149 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M86-M90
Name in latin
Osteitis deformans Paget
Similar endpoints
↥List of similar endpoints to
Paget disease
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1125 | 513 | 598 |
| Only index persons | 891 | 427 | 464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.25 | 66.30 | 66.15 |
| Only index persons | 64.97 | 63.99 | 65.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 149 | 60 | 89 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | 65.96 | 65.73 | 66.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_PAGET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PAGET | 1.012 [0.76, 1.35] | 0.938 |
| Birth year | 0.999 [0.99, 1.01] | 0.783 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 317 females with M13_PAGET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PAGET | 1.119 [0.88, 1.43] | 0.362 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 382 males with M13_PAGET died.
Mortality risk
Mortality risk for people of age
years, who have M13_PAGET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.261% |
| 5 | 0.632% | 1.405% |
| 10 | 1.7% | 3.576% |
| 15 | 3.327% | 6.476% |
| 20 | 6.058% | 11.352% |
Relationships between endpoints
↥Index endpoint: M13_PAGET – Paget disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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