musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
218 |
4. Check minimum number of eventsNone |
218 |
5. Include endpointsNone |
218 |
6. Filter based on genotype QC (FinnGen only) |
211 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Osteopathy in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1723 | 895 | 807 |
| Only index persons | 1430 | 752 | 678 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 67.00 | 67.82 | 66.10 |
| Only index persons | 66.54 | 67.84 | 65.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 211 | 111 | 100 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 65.46 | 64.26 | 66.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_OSTEOPATHYINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OSTEOPATHYINOTH | 9.092 [6.48, 12.75] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.114 |
During the follow-up period (1.1.1998 — 31.12.2019), 430 out of 733 females with M13_OSTEOPATHYINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_OSTEOPATHYINOTH | 7.116 [4.53, 11.17] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 356 out of 636 males with M13_OSTEOPATHYINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_OSTEOPATHYINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.763% | 1.031% |
| 5 | 4.847% | 6.694% |
| 10 | 12.775% | 16.411% |
| 15 | 22.181% | 29.36% |
| 20 | 35.371% | 45.528% |
Relationships between endpoints
↥Index endpoint: M13_OSTEOPATHYINOTH – Osteopathy in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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