≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Osteomyelitis

DOID EFO Endpoint Browser PheWeb

M13_OSTEOMYELITIS

osteomyelitis: An acute or chronic inflammation of the bone and its structures due to infection with pyogenic bacteria.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M86
  • Hospital discharge: ICD-9 — 730[0-9]
  • Hospital discharge: ICD-8 — 720
  • Cause of death: ICD-10 — M86
  • Cause of death: ICD-9 — 730[0-9]
  • Cause of death: ICD-8 — 720

2 out of 7 registries used, show all original rules.

2201

4. Check minimum number of events

None

2201

5. Include endpoints

None

2201

6. Filter based on genotype QC (FinnGen only)

2125

Control definitions (FinnGen only)

Control exclude M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M86-M90
Name in latin Osteomyelitis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 20834 7885 12713
Only index persons 16258 6276 9982
Unadjusted period prevalence (%)
Whole population 0.31 0.23 0.36
Only index persons 0.32 0.23 0.38
Median age at first event (years)
Whole population 57.81 58.94 57.03
Only index persons 56.16 56.85 55.72

-FinnGen-

Key figures

All Female Male
Number of individuals 2125 756 1369
Unadjusted period prevalence (%) 0.55 0.30 0.69
Median age at first event (years) 58.16 53.20 60.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint M13_OSTEOMYELITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_OSTEOMYELITIS 3.246 [2.73, 3.85] < 0.001
Birth year 0.995 [0.99, 1.0] 0.203

During the follow-up period (1.1.1998 — 31.12.2019), 1756 out of 4680 females with M13_OSTEOMYELITIS died.

Males

Parameter HR [95% CI] p-value
M13_OSTEOMYELITIS 3.081 [2.69, 3.53] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 2976 out of 7768 males with M13_OSTEOMYELITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_OSTEOMYELITIS.

N-year risk Females Males
1 0.376% 0.552%
5 2.027% 3.266%
10 4.818% 7.928%
15 8.702% 15.514%
20 15.549% 26.173%

Relationships between endpoints

↥

Index endpoint: M13_OSTEOMYELITIS – Osteomyelitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data