No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: 16<=EVENT_AGE<=44 Registry filters:
3 out of 7 registries used, show all original rules. |
11265 |
4. Check minimum number of eventsNone |
11265 |
5. Include endpointsNone |
11265 |
6. Filter based on genotype QC (FinnGen only) |
10867 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF10
Early lumbar disc prolapse, operated
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 91713 | 40838 | 50386 |
| Only index persons | 90026 | 40442 | 49584 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.30 | 1.17 | 1.41 |
| Only index persons | 1.71 | 1.49 | 1.89 |
| Median age at first event (years) | |||
| Whole population | 35.38 | 35.54 | 35.25 |
| Only index persons | 35.35 | 35.52 | 35.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 10867 | 6435 | 4432 |
| Unadjusted period prevalence (%) | 2.40 | 2.53 | 2.23 |
| Median age at first event (years) | 36.39 | 36.06 | 36.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_EARLY_LUMBAR_PROLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_EARLY_LUMBAR_PROLAPSE | 1.169 [1.03, 1.33] | 0.016 |
| Birth year | 0.99 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 557 out of 35605 females with M13_EARLY_LUMBAR_PROLAPSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_EARLY_LUMBAR_PROLAPSE | 1.043 [0.95, 1.15] | 0.398 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1489 out of 43720 males with M13_EARLY_LUMBAR_PROLAPSE died.
Mortality risk
Mortality risk for people of age
years, who have M13_EARLY_LUMBAR_PROLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.086% | 0.178% |
| 5 | 0.597% | 1.141% |
| 10 | 1.496% | 2.791% |
| 15 | 2.793% | 5.433% |
| 20 | 5.138% | 9.355% |
Relationships between endpoints
↥Index endpoint: M13_EARLY_LUMBAR_PROLAPSE – Early lumbar disc prolapse, operated
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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