cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).
Other specified/unspecified disorders of bone/cartilage
DOID EFO Endpoint Browser PheWeb
M13_BONEDISNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
953 |
4. Check minimum number of eventsNone |
953 |
5. Include endpointsNone |
953 |
6. Filter based on genotype QC (FinnGen only) |
932 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified disorders of bone/cartilage
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8627 | 3501 | 5069 |
| Only index persons | 7527 | 3030 | 4497 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.14 |
| Only index persons | 0.15 | 0.11 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 30.25 | 43.37 | 20.93 |
| Only index persons | 28.79 | 40.76 | 20.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 932 | 424 | 508 |
| Unadjusted period prevalence (%) | 0.21 | 0.17 | 0.26 |
| Median age at first event (years) | 31.39 | 41.59 | 22.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.434 [1.18, 1.74] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.203 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 1536 females with M13_BONEDISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.396 [1.14, 1.7] | 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 1231 males with M13_BONEDISNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.265% |
| 5 | 0.864% | 1.517% |
| 10 | 2.15% | 3.733% |
| 15 | 3.897% | 7.014% |
| 20 | 7.024% | 12.433% |
Relationships between endpoints
↥Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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