reflex sympathetic dystrophy: Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome (see this term) in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1133 |
4. Check minimum number of eventsNone |
1133 |
5. Include endpointsNone |
1133 |
6. Filter based on genotype QC (FinnGen only) |
1066 |
Control definitions (FinnGen only)
Control exclude
M13_OSTEOCHONDRO
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M89
Name in latin
Algoneurodystrophia
Similar endpoints
↥List of similar endpoints to
Algoneurodystrophy
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8238 | 5702 | 2485 |
| Only index persons | 7987 | 5588 | 2399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.16 | 0.07 |
| Only index persons | 0.17 | 0.21 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 47.60 | 47.38 | 48.14 |
| Only index persons | 47.48 | 47.27 | 47.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1066 | 820 | 246 |
| Unadjusted period prevalence (%) | 0.28 | 0.32 | 0.12 |
| Median age at first event (years) | 46.69 | 45.83 | 49.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_ALGONEURO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ALGONEURO | 1.12 [0.97, 1.29] | 0.115 |
| Birth year | 0.992 [0.98, 1.0] | 0.07 |
During the follow-up period (1.1.1998 — 31.12.2019), 340 out of 4998 females with M13_ALGONEURO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ALGONEURO | 1.281 [1.09, 1.5] | 0.002 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 2184 males with M13_ALGONEURO died.
Mortality risk
Mortality risk for people of age
years, who have M13_ALGONEURO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.313% |
| 5 | 0.559% | 1.621% |
| 10 | 1.49% | 3.979% |
| 15 | 2.957% | 7.149% |
| 20 | 5.213% | 11.809% |
Relationships between endpoints
↥Index endpoint: M13_ALGONEURO – Algoneurodystrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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