seborrheic dermatitis: A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3492 |
4. Check minimum number of eventsNone |
3492 |
5. Include endpointsNone |
3492 |
6. Filter based on genotype QC (FinnGen only) |
3382 |
Control definitions (FinnGen only)
Control exclude
L12_DERMATITISECZEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L20-L30
Name in latin
Eczema seborrhoicum
Similar endpoints
↥List of similar endpoints to
Seborrhoeic dermatitis
based on the number of shared cases.
Similar with more cases:
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27055 | 10631 | 16244 |
| Only index persons | 24323 | 9856 | 14467 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.39 | 0.30 | 0.45 |
| Only index persons | 0.48 | 0.36 | 0.55 |
| Median age at first event (years) | |||
| Whole population | 51.96 | 48.40 | 54.18 |
| Only index persons | 51.03 | 48.14 | 52.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3382 | 1447 | 1935 |
| Unadjusted period prevalence (%) | 0.80 | 0.57 | 0.97 |
| Median age at first event (years) | 55.00 | 49.32 | 59.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_SEBORRHOEIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_SEBORRHOEIC | 1.348 [1.2, 1.51] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.629 |
During the follow-up period (1.1.1998 — 31.12.2019), 994 out of 7697 females with L12_SEBORRHOEIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_SEBORRHOEIC | 1.588 [1.43, 1.76] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 2798 out of 12088 males with L12_SEBORRHOEIC died.
Mortality risk
Mortality risk for people of age
years, who have L12_SEBORRHOEIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.166% | 0.342% |
| 5 | 0.864% | 1.963% |
| 10 | 2.087% | 4.8% |
| 15 | 4.28% | 8.967% |
| 20 | 7.508% | 15.394% |
Relationships between endpoints
↥Index endpoint: L12_SEBORRHOEIC – Seborrhoeic dermatitis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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