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Pruritus

EFO MESH Endpoint Browser PheWeb

L12_PRURITUS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L29
  • Hospital discharge: ICD-9 — 698[0-1]|698[8-9]
  • Hospital discharge: ICD-8 — 698[0-1]|6989
  • Cause of death: ICD-10 — L29
  • Cause of death: ICD-9 — 698[0-1]|698[8-9]
  • Cause of death: ICD-8 — 698[0-1]|6989

2 out of 7 registries used, show all original rules.

3996

4. Check minimum number of events

None

3996

5. Include endpoints

None

3996

6. Filter based on genotype QC (FinnGen only)

3819

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L20-L30
Name in latin Pruritus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 31252 21491 9458
Only index persons 26923 19268 7655
Unadjusted period prevalence (%)
Whole population 0.51 0.62 0.26
Only index persons 0.59 0.71 0.29
Median age at first event (years)
Whole population 54.66 52.22 60.21
Only index persons 53.41 51.58 58.02

-FinnGen-

Key figures

All Female Male
Number of individuals 3819 2776 1043
Unadjusted period prevalence (%) 0.94 1.09 0.52
Median age at first event (years) 55.52 51.95 65.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_PRURITUS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PRURITUS 1.402 [1.27, 1.55] < 0.001
Birth year 0.997 [0.99, 1.0] 0.428

During the follow-up period (1.1.1998 — 31.12.2019), 2846 out of 15566 females with L12_PRURITUS died.

Males

Parameter HR [95% CI] p-value
L12_PRURITUS 1.803 [1.58, 2.06] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 2215 out of 6802 males with L12_PRURITUS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PRURITUS.

N-year risk Females Males
1 0.135% 0.359%
5 0.81% 2.284%
10 2.09% 5.288%
15 4.002% 9.525%
20 7.052% 15.846%

Relationships between endpoints

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Index endpoint: L12_PRURITUS – Pruritus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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