bullous pemphigoid: Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
626 |
4. Check minimum number of eventsNone |
626 |
5. Include endpointsNone |
626 |
6. Filter based on genotype QC (FinnGen only) |
609 |
Control definitions (FinnGen only)
Control exclude
L12_BULLOUS
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L12
Name in latin
Pemphigoides bullosus
Similar endpoints
↥List of similar endpoints to
Bullous pemphigoid
based on the number of shared cases.
Similar with more cases:
- Pemphigoid
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6427 | 3635 | 2742 |
| Only index persons | 5536 | 3158 | 2378 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 78.57 | 79.60 | 77.21 |
| Only index persons | 78.21 | 79.15 | 76.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 609 | 290 | 319 |
| Unadjusted period prevalence (%) | 0.14 | 0.11 | 0.16 |
| Median age at first event (years) | 73.82 | 72.80 | 74.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGOID_BULL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_BULL | 1.818 [1.56, 2.12] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 1650 out of 3117 females with L12_PEMPHIGOID_BULL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_BULL | 1.918 [1.57, 2.35] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 1263 out of 2311 males with L12_PEMPHIGOID_BULL died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGOID_BULL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.439% |
| 5 | 0.984% | 2.339% |
| 10 | 2.302% | 6.252% |
| 15 | 4.504% | 11.913% |
| 20 | 7.97% | 19.969% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGOID_BULL – Bullous pemphigoid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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