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Other contact dermatitis

DOID EFO Endpoint Browser PheWeb

L12_OTHERCONTACT

contact dermatitis: An inflammatory skin condition caused by direct contact between the skin and either an irritating substance or an allergen.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L24, L25
  • Hospital discharge: ICD-9 — 692
  • Hospital discharge: ICD-8 — 692[1-6]|69281
  • Hospital discharge: excluded ICD-9 — 6920B|6921B|6922B|6924B|6924D|6924H|6924L|6925B|6925D|6926B|6926D
  • Hospital discharge: excluded ICD-8 — 6925
  • Cause of death: ICD-10 — L24, L25
  • Cause of death: ICD-9 — 692
  • Cause of death: ICD-8 — 692[1-6]|69281
  • Cause of death: excluded ICD-9 — 6920B|6921B|6922B|6924B|6924D|6924H|6924L|6925B|6925D|6926B|6926D
  • Cause of death: excluded ICD-8 — 6925

2 out of 7 registries used, show all original rules.

3190

4. Check minimum number of events

None

3190

5. Include endpoints

None

3190

6. Filter based on genotype QC (FinnGen only)

3078

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 34509 20117 14037
Only index persons 27113 16838 10275
Unadjusted period prevalence (%)
Whole population 0.50 0.58 0.39
Only index persons 0.53 0.62 0.39
Median age at first event (years)
Whole population 43.75 43.86 43.20
Only index persons 38.73 39.87 36.87

-FinnGen-

Key figures

All Female Male
Number of individuals 3078 1960 1118
Unadjusted period prevalence (%) 0.69 0.77 0.56
Median age at first event (years) 41.39 39.66 44.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_OTHERCONTACT and mortality.

Females

Parameter HR [95% CI] p-value
L12_OTHERCONTACT 1.083 [0.95, 1.23] 0.22
Birth year 0.995 [0.99, 1.0] 0.214

During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 10345 females with L12_OTHERCONTACT died.

Males

Parameter HR [95% CI] p-value
L12_OTHERCONTACT 1.193 [1.06, 1.34] 0.003
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 493 out of 4970 males with L12_OTHERCONTACT died.

Mortality risk

Mortality risk for people of age

years, who have L12_OTHERCONTACT.

N-year risk Females Males
1 0.094% 0.231%
5 0.58% 1.444%
10 1.461% 3.579%
15 2.911% 6.647%
20 5.288% 11.456%

Relationships between endpoints

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Index endpoint: L12_OTHERCONTACT – Other contact dermatitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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