atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
353 |
4. Check minimum number of eventsNone |
353 |
5. Include endpointsNone |
353 |
6. Filter based on genotype QC (FinnGen only) |
347 |
Control definitions (FinnGen only)
Control exclude
L12_DERMATITISECZEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L20-L30
Name in latin
Erythrodermia universalis NAS
Similar endpoints
↥List of similar endpoints to
Exfoliative dermatitis
based on the number of shared cases.
Similar with more cases:
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3058 | 1077 | 1960 |
| Only index persons | 2575 | 944 | 1631 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.03 | 0.05 |
| Only index persons | 0.05 | 0.03 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 61.96 | 61.58 | 62.08 |
| Only index persons | 60.41 | 60.15 | 60.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 347 | 102 | 245 |
| Unadjusted period prevalence (%) | 0.10 | 0.04 | 0.12 |
| Median age at first event (years) | 61.13 | 54.39 | 63.93 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_EXFOLIATIVE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_EXFOLIATIVE | 2.068 [1.66, 2.57] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 324 out of 966 females with L12_EXFOLIATIVE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_EXFOLIATIVE | 2.357 [1.97, 2.82] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 723 out of 1728 males with L12_EXFOLIATIVE died.
Mortality risk
Mortality risk for people of age
years, who have L12_EXFOLIATIVE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.419% |
| 5 | 1.185% | 2.546% |
| 10 | 2.717% | 6.481% |
| 15 | 5.238% | 11.839% |
| 20 | 9.028% | 19.972% |
Relationships between endpoints
↥Index endpoint: L12_EXFOLIATIVE – Exfoliative dermatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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