erythematosquamous dermatosis: Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. Many skin problems, such as acne, also affect your appearance.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1145 |
6. Filter based on genotype QC (FinnGen only) |
1097 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other erythematous conditions
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10019 | 5986 | 3954 |
| Only index persons | 8013 | 5008 | 3005 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.17 | 0.11 |
| Only index persons | 0.16 | 0.18 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 49.22 | 52.43 | 44.24 |
| Only index persons | 48.59 | 51.84 | 43.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1097 | 702 | 395 |
| Unadjusted period prevalence (%) | 0.25 | 0.28 | 0.20 |
| Median age at first event (years) | 53.21 | 52.66 | 54.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ERYTHEMATOUSOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMATOUSOTH | 1.367 [1.2, 1.56] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.795 |
During the follow-up period (1.1.1998 — 31.12.2019), 596 out of 3698 females with L12_ERYTHEMATOUSOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMATOUSOTH | 1.759 [1.44, 2.15] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 2261 males with L12_ERYTHEMATOUSOTH died.
Mortality risk
Mortality risk for people of age
years, who have L12_ERYTHEMATOUSOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.311% |
| 5 | 0.941% | 1.697% |
| 10 | 2.352% | 4.431% |
| 15 | 4.349% | 8.339% |
| 20 | 7.553% | 13.454% |
Relationships between endpoints
↥Index endpoint: L12_ERYTHEMATOUSOTH – Other erythematous conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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