erythema infectiosum: usually a benign childhood condition characterized by a classic slapped-cheek appearance (see the image below) and lacy exanthem.It results from infection with human parvovirus (PV) B19, an erythrovirus.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1018 |
4. Check minimum number of eventsNone |
1018 |
5. Include endpointsNone |
1018 |
6. Filter based on genotype QC (FinnGen only) |
982 |
Control definitions (FinnGen only)
Control exclude
L12_URTICARIAERYTHEMA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50-L54
Name in latin
Erythema nodosum
Similar endpoints
↥List of similar endpoints to
Erythema nodosum
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9004 | 6843 | 2116 |
| Only index persons | 7799 | 5941 | 1858 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.20 | 0.06 |
| Only index persons | 0.18 | 0.22 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 40.55 | 41.91 | 36.01 |
| Only index persons | 37.81 | 38.86 | 34.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 982 | 776 | 206 |
| Unadjusted period prevalence (%) | 0.26 | 0.30 | 0.10 |
| Median age at first event (years) | 38.65 | 38.10 | 40.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_ERYTHEMANODOSUM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMANODOSUM | 1.225 [1.06, 1.41] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 380 out of 3301 females with L12_ERYTHEMANODOSUM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMANODOSUM | 1.581 [1.26, 1.98] | < 0.001 |
| Birth year | 0.984 [0.97, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 148 out of 1122 males with L12_ERYTHEMANODOSUM died.
Mortality risk
Mortality risk for people of age
years, who have L12_ERYTHEMANODOSUM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.252% |
| 5 | 0.531% | 1.652% |
| 10 | 1.452% | 4.087% |
| 15 | 2.738% | 7.634% |
| 20 | 5.092% | 12.892% |
Relationships between endpoints
↥Index endpoint: L12_ERYTHEMANODOSUM – Erythema nodosum
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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