erythema multiforme: Erythema multiforme (EM) refers to a group ofhypersensitivity disorders characterized by symmetric red, patchy lesions, primarily on the arms and legs. The cause is unknown, but EM frequently occurs in association with herpes simplex virus , suggesting an immunologic process initiated by the virus. In half of the cases, the triggering agents appear to be medications, including anticonvulsants, sulfonamides, nonsteroidal anti-inflammatory drugs, and other antibiotics. In addition, some cases appear to be associated with infectious organisms such as Mycoplasma pneumoniae and many viral agents. Erythema multiforme is the mildest of three skin disorders that are often discussed in relation to each other. It is generally the mildest of the three. More severe is Stevens-Johnson syndrome . The most severe of the three is toxic epidermal necrolysis (TEN).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
775 |
4. Check minimum number of eventsNone |
775 |
5. Include endpointsNone |
775 |
6. Filter based on genotype QC (FinnGen only) |
754 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to
Erythema multiforme
based on the number of shared cases.
Similar with more cases:
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7231 | 3832 | 3367 |
| Only index persons | 6249 | 3374 | 2875 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.11 | 0.09 |
| Only index persons | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 43.65 | 47.82 | 38.77 |
| Only index persons | 42.72 | 46.91 | 37.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 754 | 467 | 287 |
| Unadjusted period prevalence (%) | 0.17 | 0.18 | 0.14 |
| Median age at first event (years) | 48.44 | 45.41 | 53.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ERYTHEMAMULTIF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMAMULTIF | 1.578 [1.37, 1.82] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 521 out of 2889 females with L12_ERYTHEMAMULTIF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ERYTHEMAMULTIF | 1.557 [1.32, 1.83] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 415 out of 2388 males with L12_ERYTHEMAMULTIF died.
Mortality risk
Mortality risk for people of age
years, who have L12_ERYTHEMAMULTIF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.167% | 0.238% |
| 5 | 0.852% | 1.464% |
| 10 | 2.022% | 3.826% |
| 15 | 3.886% | 7.226% |
| 20 | 6.825% | 12.223% |
Relationships between endpoints
↥Index endpoint: L12_ERYTHEMAMULTIF – Erythema multiforme
GWS hits: -
Loading data