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Atopic dermatitis

DOID EFO Endpoint Browser PheWeb

L12_ATOPIC

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — L20
  • Hospital discharge: ICD-10 — L20
  • Hospital discharge: ICD-9 — 6918
  • Hospital discharge: ICD-8 — 691
  • Hospital discharge: excluded ICD-9 — 6918X
  • Cause of death: ICD-10 — L20
  • Cause of death: ICD-9 — 6918
  • Cause of death: ICD-8 — 691
  • Cause of death: excluded ICD-9 — 6918X
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — L20

4 out of 7 registries used, show all original rules.

27993

4. Check minimum number of events

None

27993

5. Include endpoints

None

27993

6. Filter based on genotype QC (FinnGen only)

26905

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF11
Parent code in ICD-10 L20-L30
Name in latin Dermatitis atopica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 26905 19077 7828
Unadjusted period prevalence (%) 6.46 7.49 3.93
Median age at first event (years) 33.91 33.27 35.48

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

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Index endpoint: L12_ATOPIC – Atopic dermatitis

GWS hits: 67

This endpoint is excluded (different definition than used in FinnGen).