pancreas disease: A non-neoplastic or neoplastic disorder that affects the pancreas. Representative examples of non-neoplastic disorders include pancreatitis and pancreatic insufficiency. Representative examples of neoplastic disorders include cystadenomas, carcinomas, lymphomas, and neuroendocrine neoplasms. [ NCIT:C26842 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2410 |
4. Check minimum number of eventsNone |
2410 |
5. Include endpointsNone |
2410 |
6. Filter based on genotype QC (FinnGen only) |
2350 |
Control definitions (FinnGen only)
Control exclude
K11_GALLBILPANC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other diseases of pancreas
based on the number of shared cases.
Similar with more cases:
- Disorders of gallbladder, biliary tract and pancreas
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19140 | 7325 | 11621 |
| Only index persons | 15380 | 6381 | 8999 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.28 | 0.21 | 0.32 |
| Only index persons | 0.30 | 0.23 | 0.34 |
| Median age at first event (years) | |||
| Whole population | 57.67 | 63.33 | 54.11 |
| Only index persons | 58.65 | 63.39 | 55.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2350 | 1049 | 1301 |
| Unadjusted period prevalence (%) | 0.55 | 0.41 | 0.65 |
| Median age at first event (years) | 62.09 | 63.41 | 61.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_PANCOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PANCOTH | 2.351 [2.06, 2.68] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.233 |
During the follow-up period (1.1.1998 — 31.12.2019), 1469 out of 4844 females with K11_PANCOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PANCOTH | 3.481 [3.08, 3.93] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2791 out of 7539 males with K11_PANCOTH died.
Mortality risk
Mortality risk for people of age
years, who have K11_PANCOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.236% | 0.627% |
| 5 | 1.415% | 3.53% |
| 10 | 3.405% | 8.57% |
| 15 | 6.261% | 16.419% |
| 20 | 10.99% | 26.163% |
Relationships between endpoints
↥Index endpoint: K11_PANCOTH – Other diseases of pancreas
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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