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Other noninfective gastroenteritis and colitis

DOID EFO Endpoint Browser PheWeb

K11_OTHENTERCOL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K52
  • Hospital discharge: ICD-9 — 558|5564A
  • Hospital discharge: ICD-8 — 562|5639
  • Cause of death: ICD-10 — K52
  • Cause of death: ICD-9 — 558|5564A
  • Cause of death: ICD-8 — 562|5639

2 out of 7 registries used, show all original rules.

10339

4. Check minimum number of events

None

10339

5. Include endpoints

None

10339

6. Filter based on genotype QC (FinnGen only)

9990

Control definitions (FinnGen only)

Control exclude K11_ENERCOLNONINF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50-K52
Name in latin Alia gastroenteritis et/sive colitis non infectiosa

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 120944 64388 55645
Only index persons 89205 48606 40599
Unadjusted period prevalence (%)
Whole population 1.70 1.84 1.55
Only index persons 1.68 1.79 1.55
Median age at first event (years)
Whole population 40.11 50.84 27.28
Only index persons 39.20 48.41 28.16

-FinnGen-

Key figures

All Female Male
Number of individuals 9990 5958 4032
Unadjusted period prevalence (%) 2.21 2.34 2.02
Median age at first event (years) 51.74 50.25 53.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHENTERCOL and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHENTERCOL 1.789 [1.63, 1.96] < 0.001
Birth year 0.993 [0.99, 1.0] 0.096

During the follow-up period (1.1.1998 — 31.12.2019), 8835 out of 45377 females with K11_OTHENTERCOL died.

Males

Parameter HR [95% CI] p-value
K11_OTHENTERCOL 1.93 [1.73, 2.15] < 0.001
Birth year 0.988 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 6320 out of 40003 males with K11_OTHENTERCOL died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHENTERCOL.

N-year risk Females Males
1 0.131% 0.295%
5 0.987% 2.133%
10 2.305% 5.316%
15 4.474% 10.15%
20 7.7% 17.409%

Relationships between endpoints

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Index endpoint: K11_OTHENTERCOL – Other noninfective gastroenteritis and colitis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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