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Other diseases of appendix

DOID EFO Endpoint Browser PheWeb

K11_OTHAPPEND

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K38
  • Hospital discharge: ICD-9 — 543
  • Hospital discharge: ICD-8 — 543
  • Cause of death: ICD-10 — K38
  • Cause of death: ICD-9 — 543
  • Cause of death: ICD-8 — 543

2 out of 7 registries used, show all original rules.

377

4. Check minimum number of events

None

377

5. Include endpoints

None

377

6. Filter based on genotype QC (FinnGen only)

365

Control definitions (FinnGen only)

Control exclude K11_APPENDIX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K35-K38
Name in latin Alii morbi appendicis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3360 2099 1235
Only index persons 2823 1812 1011
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.06 0.07 0.04
Median age at first event (years)
Whole population 37.74 37.44 37.89
Only index persons 33.98 34.08 33.82

-FinnGen-

Key figures

All Female Male
Number of individuals 365 250 115
Unadjusted period prevalence (%) 0.09 0.10 0.06
Median age at first event (years) 36.32 34.38 40.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint K11_OTHAPPEND and mortality.

Females

Parameter HR [95% CI] p-value
K11_OTHAPPEND 1.183 [0.87, 1.6] 0.277
Birth year 0.996 [0.99, 1.0] 0.385

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 525 females with K11_OTHAPPEND died.

Males

Parameter HR [95% CI] p-value
K11_OTHAPPEND 1.303 [0.91, 1.86] 0.142
Birth year 0.989 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 371 males with K11_OTHAPPEND died.

Mortality risk

Mortality risk for people of age

years, who have K11_OTHAPPEND.

N-year risk Females Males
1 0.09% 0.251%
5 0.711% 1.634%
10 1.591% 4.017%
15 3.205% 7.607%
20 6.275% 13.089%

Relationships between endpoints

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Index endpoint: K11_OTHAPPEND – Other diseases of appendix

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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