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Tooth agenesis EXCLUDE clefts and syndromes

Endpoint Browser PheWeb

K11_HYPO_ONLY

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • not K11_CLEFT_SYNDR
472532

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — K00.00
  • Hospital discharge: ICD-10 — K00.00
  • Hospital discharge: ICD-9 — 5200A
  • Hospital discharge: ICD-8 — 52000
  • Cause of death: ICD-10 — K00.00
  • Cause of death: ICD-9 — 5200A
  • Cause of death: ICD-8 — 52000

3 out of 7 registries used, show all original rules.

1388

4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

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Control definitions (FinnGen only)

Control conditions not K11_CLEFT_SYNDR

Extra metadata

First used in FinnGen datafreeze DF10

Similar endpoints

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List of similar endpoints to Tooth agenesis EXCLUDE clefts and syndromes based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

None

Venn diagram with a set fully inside an highlighted set Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37565 21955 15575
Only index persons 32984 19326 13658
Unadjusted period prevalence (%)
Whole population 0.55 0.63 0.44
Only index persons 0.63 0.71 0.52
Median age at first event (years)
Whole population 12.21 12.26 12.09
Only index persons 12.85 12.96 12.68

-FinnGen-

Key figures

All Female Male
Number of individuals 1337 977 360
Unadjusted period prevalence (%) 0.33 0.38 0.18
Median age at first event (years) 20.26 19.71 21.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_HYPO_ONLY and mortality.

Females

Parameter HR [95% CI] p-value
K11_HYPO_ONLY 1.193 [0.89, 1.61] 0.245
Birth year 0.992 [0.98, 1.0] 0.07

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 17984 females with K11_HYPO_ONLY died.

Males

Parameter HR [95% CI] p-value
K11_HYPO_ONLY 0.962 [0.71, 1.31] 0.805
Birth year 0.989 [0.98, 1.0] 0.029

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 12761 males with K11_HYPO_ONLY died.

Mortality risk

Mortality risk for people of age

years, who have K11_HYPO_ONLY.

N-year risk Females Males
1 0.111% 0.2%
5 0.683% 1.062%
10 1.67% 2.862%
15 2.925% 5.365%
20 5.103% 9.419%

Relationships between endpoints

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Index endpoint: K11_HYPO_ONLY – Tooth agenesis EXCLUDE clefts and syndromes

GWS hits: 11

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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