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Other diseases of gallbladder

DOID EFO Endpoint Browser PheWeb

K11_GALLBLAOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K82
  • Hospital discharge: ICD-9 — 575[3-9]
  • Hospital discharge: ICD-8 — 57600|57602|57604
  • Cause of death: ICD-10 — K82
  • Cause of death: ICD-9 — 575[3-9]
  • Cause of death: ICD-8 — 57600|57602|57604

2 out of 7 registries used, show all original rules.

1536

4. Check minimum number of events

None

1536

5. Include endpoints

None

1536

6. Filter based on genotype QC (FinnGen only)

1469

Control definitions (FinnGen only)

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K80-K87
Name in latin Alii morbi vesicae biliaris

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14816 9612 5039
Only index persons 11458 7755 3703
Unadjusted period prevalence (%)
Whole population 0.23 0.28 0.14
Only index persons 0.24 0.29 0.14
Median age at first event (years)
Whole population 53.44 50.94 58.14
Only index persons 50.54 48.38 55.05

-FinnGen-

Key figures

All Female Male
Number of individuals 1469 915 554
Unadjusted period prevalence (%) 0.33 0.36 0.28
Median age at first event (years) 49.78 45.30 57.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_GALLBLAOTH and mortality.

Females

Parameter HR [95% CI] p-value
K11_GALLBLAOTH 1.493 [1.32, 1.69] < 0.001
Birth year 0.991 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 860 out of 3457 females with K11_GALLBLAOTH died.

Males

Parameter HR [95% CI] p-value
K11_GALLBLAOTH 1.511 [1.32, 1.74] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 816 out of 2490 males with K11_GALLBLAOTH died.

Mortality risk

Mortality risk for people of age

years, who have K11_GALLBLAOTH.

N-year risk Females Males
1 0.177% 0.305%
5 0.953% 1.729%
10 1.97% 4.354%
15 3.672% 8.803%
20 6.419% 14.59%

Relationships between endpoints

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Index endpoint: K11_GALLBLAOTH – Other diseases of gallbladder

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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