No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 3 out of 7 registries used, show all original rules. |
46262 |
4. Check minimum number of events
Min. number of events
3
|
46262 |
5. Include endpointsNone |
46262 |
6. Filter based on genotype QC (FinnGen only) |
44590 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Constipation
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 455234 | 275461 | 176474 |
| Only index persons | 380008 | 236419 | 143589 |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.71 | 7.89 | 4.93 |
| Only index persons | 7.48 | 8.69 | 5.48 |
| Median age at first event (years) | |||
| Whole population | 66.50 | 66.96 | 65.68 |
| Only index persons | 65.34 | 65.72 | 64.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 44590 | 26872 | 17718 |
| Unadjusted period prevalence (%) | 9.90 | 10.55 | 8.90 |
| Median age at first event (years) | 61.54 | 58.28 | 66.49 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_CONSTIPATION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CONSTIPATION | 1.437 [1.33, 1.55] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.169 |
During the follow-up period (1.1.1998 — 31.12.2019), 70758 out of 220583 females with K11_CONSTIPATION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CONSTIPATION | 1.745 [1.6, 1.91] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 52445 out of 142374 males with K11_CONSTIPATION died.
Mortality risk
Mortality risk for people of age
years, who have K11_CONSTIPATION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.307% |
| 5 | 0.769% | 1.696% |
| 10 | 1.769% | 4.346% |
| 15 | 3.327% | 7.874% |
| 20 | 5.987% | 13.488% |
Relationships between endpoints
↥Index endpoint: K11_CONSTIPATION – Constipation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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