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Cholecystitis

DOID EFO Endpoint Browser PheWeb

K11_CHOLECYST

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K81
  • Hospital discharge: ICD-9 — 575[0-1]
  • Hospital discharge: ICD-8 — 5750[0-3]
  • Cause of death: ICD-10 — K81
  • Cause of death: ICD-9 — 575[0-1]
  • Cause of death: ICD-8 — 5750[0-3]

2 out of 7 registries used, show all original rules.

5441

4. Check minimum number of events

None

5441

5. Include endpoints

None

5441

6. Filter based on genotype QC (FinnGen only)

5237

Control definitions (FinnGen only)

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K80-K87
Name in latin Cholecystitis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 62108 32346 29007
Only index persons 45496 24241 21255
Unadjusted period prevalence (%)
Whole population 0.87 0.93 0.81
Only index persons 0.85 0.89 0.81
Median age at first event (years)
Whole population 65.72 64.16 67.45
Only index persons 63.44 60.65 66.62

-FinnGen-

Key figures

All Female Male
Number of individuals 5237 2411 2826
Unadjusted period prevalence (%) 1.20 0.95 1.42
Median age at first event (years) 61.48 54.13 67.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_CHOLECYST and mortality.

Females

Parameter HR [95% CI] p-value
K11_CHOLECYST 1.555 [1.42, 1.71] < 0.001
Birth year 0.993 [0.99, 1.0] 0.098

During the follow-up period (1.1.1998 — 31.12.2019), 6483 out of 17162 females with K11_CHOLECYST died.

Males

Parameter HR [95% CI] p-value
K11_CHOLECYST 1.589 [1.43, 1.76] < 0.001
Birth year 0.987 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 7076 out of 17274 males with K11_CHOLECYST died.

Mortality risk

Mortality risk for people of age

years, who have K11_CHOLECYST.

N-year risk Females Males
1 0.116% 0.234%
5 0.813% 1.706%
10 2.254% 4.341%
15 4.26% 8.344%
20 7.204% 13.939%

Relationships between endpoints

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Index endpoint: K11_CHOLECYST – Cholecystitis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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