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Other diseases of biliary tract

DOID EFO Endpoint Browser PheWeb

K11_BILIAOTH

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K83
  • Hospital discharge: ICD-9 — 576[2-9]
  • Hospital discharge: ICD-8 — 576
  • Hospital discharge: excluded ICD-10 — K83.0
  • Hospital discharge: excluded ICD-8 — 57600|57602|57604
  • Cause of death: ICD-10 — K83
  • Cause of death: ICD-9 — 576[2-9]
  • Cause of death: ICD-8 — 576
  • Cause of death: excluded ICD-10 — K83.0
  • Cause of death: excluded ICD-8 — 57600|57602|57604

2 out of 7 registries used, show all original rules.

2939

4. Check minimum number of events

None

2939

5. Include endpoints

None

2939

6. Filter based on genotype QC (FinnGen only)

2825

Control definitions (FinnGen only)

Control exclude K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K80-K87
Name in latin Alii morbi ductuum biliarium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 27646 16678 10672
Only index persons 20800 12833 7967
Unadjusted period prevalence (%)
Whole population 0.41 0.48 0.30
Only index persons 0.41 0.47 0.30
Median age at first event (years)
Whole population 64.78 64.02 66.00
Only index persons 64.53 63.33 66.48

-FinnGen-

Key figures

All Female Male
Number of individuals 2825 1560 1265
Unadjusted period prevalence (%) 0.62 0.61 0.64
Median age at first event (years) 62.19 58.38 66.89

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint K11_BILIAOTH and mortality.

Females

Parameter HR [95% CI] p-value
K11_BILIAOTH 2.99 [2.63, 3.4] < 0.001
Birth year 0.993 [0.98, 1.0] 0.068

During the follow-up period (1.1.1998 — 31.12.2019), 3777 out of 8014 females with K11_BILIAOTH died.

Males

Parameter HR [95% CI] p-value
K11_BILIAOTH 3.849 [3.24, 4.57] < 0.001
Birth year 0.99 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 3298 out of 6178 males with K11_BILIAOTH died.

Mortality risk

Mortality risk for people of age

years, who have K11_BILIAOTH.

N-year risk Females Males
1 0.218% 0.871%
5 1.37% 4.964%
10 3.625% 11.839%
15 7.078% 21.351%
20 12.539% 34.164%

Relationships between endpoints

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Index endpoint: K11_BILIAOTH – Other diseases of biliary tract

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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