appendicitis: Acute inflammation of the vermiform appendix.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3225 |
4. Check minimum number of eventsNone |
3225 |
5. Include endpointsNone |
3225 |
6. Filter based on genotype QC (FinnGen only) |
3101 |
Control definitions (FinnGen only)
Control exclude
K11_APPENDIX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other appendicitis
based on the number of shared cases.
Similar with more cases:
- Appendicitis, broad definition
- Diseases of appendix
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30807 | 15923 | 14710 |
| Only index persons | 27597 | 14579 | 13018 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.46 | 0.41 |
| Only index persons | 0.52 | 0.54 | 0.50 |
| Median age at first event (years) | |||
| Whole population | 26.65 | 26.67 | 26.39 |
| Only index persons | 25.39 | 25.68 | 25.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3101 | 1819 | 1282 |
| Unadjusted period prevalence (%) | 0.69 | 0.71 | 0.64 |
| Median age at first event (years) | 27.44 | 25.91 | 29.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_APPENDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APPENDOTH | 1.152 [0.93, 1.43] | 0.2 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 155 out of 3277 females with K11_APPENDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_APPENDOTH | 1.066 [0.88, 1.3] | 0.52 |
| Birth year | 0.991 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 202 out of 3197 males with K11_APPENDOTH died.
Mortality risk
Mortality risk for people of age
years, who have K11_APPENDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.285% |
| 5 | 0.562% | 1.552% |
| 10 | 1.442% | 3.661% |
| 15 | 2.692% | 6.828% |
| 20 | 4.667% | 11.537% |
Relationships between endpoints
↥Index endpoint: K11_APPENDOTH – Other appendicitis
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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