pulmonary edema: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
604 |
4. Check minimum number of eventsNone |
604 |
5. Include endpointsNone |
604 |
6. Filter based on genotype QC (FinnGen only) |
572 |
Control definitions (FinnGen only)
Control exclude
J10_INTERSTITIUM
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
J80-J84
Name in latin
Oedema pulmonum
Similar endpoints
↥List of similar endpoints to
Pulmonary oedema
based on the number of shared cases.
Similar with more cases:
- Other respiratory diseases principally affecting the interstitium
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
- ILD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9006 | 4604 | 4219 |
| Only index persons | 5204 | 2779 | 2425 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.13 | 0.12 |
| Only index persons | 0.10 | 0.10 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 77.49 | 80.34 | 74.43 |
| Only index persons | 76.85 | 79.98 | 73.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 572 | 199 | 373 |
| Unadjusted period prevalence (%) | 0.15 | 0.08 | 0.19 |
| Median age at first event (years) | 73.41 | 74.00 | 73.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint J10_PULMOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMOEDEMA | 3.634 [3.06, 4.32] | < 0.001 |
| Birth year | 0.996 [0.99, 1.01] | 0.435 |
During the follow-up period (1.1.1998 — 31.12.2019), 1992 out of 2704 females with J10_PULMOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_PULMOEDEMA | 4.391 [3.53, 5.47] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 1713 out of 2356 males with J10_PULMOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have J10_PULMOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.404% | 0.926% |
| 5 | 2.256% | 4.818% |
| 10 | 5.214% | 12.463% |
| 15 | 10.119% | 22.504% |
| 20 | 17.492% | 35.623% |
Relationships between endpoints
↥Index endpoint: J10_PULMOEDEMA – Pulmonary oedema
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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