cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
14574 |
4. Check minimum number of eventsNone |
14574 |
5. Include endpointsNone |
14574 |
6. Filter based on genotype QC (FinnGen only) |
14063 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I60-I69
Name in latin
Sequelae morbi cerebrovascularis
Similar endpoints
↥List of similar endpoints to
Sequelae of cerebrovascular disease
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 187076 | 86341 | 97840 |
| Only index persons | 129587 | 61348 | 68239 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.62 | 2.47 | 2.73 |
| Only index persons | 2.44 | 2.26 | 2.60 |
| Median age at first event (years) | |||
| Whole population | 75.31 | 78.32 | 72.68 |
| Only index persons | 74.63 | 77.90 | 71.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 14063 | 5387 | 8676 |
| Unadjusted period prevalence (%) | 3.50 | 2.12 | 4.36 |
| Median age at first event (years) | 70.93 | 69.53 | 71.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_SEQULAE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_SEQULAE | 2.375 [2.15, 2.62] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.097 |
During the follow-up period (1.1.1998 — 31.12.2019), 26876 out of 51453 females with I9_SEQULAE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_SEQULAE | 2.541 [2.27, 2.85] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 30878 out of 60171 males with I9_SEQULAE died.
Mortality risk
Mortality risk for people of age
years, who have I9_SEQULAE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.203% | 0.383% |
| 5 | 1.199% | 2.434% |
| 10 | 3.084% | 6.179% |
| 15 | 6.017% | 10.991% |
| 20 | 10.335% | 18.021% |
Relationships between endpoints
↥Index endpoint: I9_SEQULAE – Sequelae of cerebrovascular disease
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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