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Other diseases of pericardium

DOID EFO Endpoint Browser PheWeb

I9_PERICAOTH

Cardiac Tamponade: Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I31
  • Hospital discharge: ICD-9 — 423
  • Hospital discharge: ICD-8 — 423
  • Cause of death: ICD-10 — I31
  • Cause of death: ICD-9 — 423
  • Cause of death: ICD-8 — 423

2 out of 7 registries used, show all original rules.

1467

4. Check minimum number of events

None

1467

5. Include endpoints

None

1467

6. Filter based on genotype QC (FinnGen only)

1408

Control definitions (FinnGen only)

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Alii morbi pericardii

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10403 4567 5702
Only index persons 8065 3622 4443
Unadjusted period prevalence (%)
Whole population 0.15 0.13 0.16
Only index persons 0.15 0.13 0.17
Median age at first event (years)
Whole population 65.75 68.09 63.88
Only index persons 65.53 67.60 63.85

-FinnGen-

Key figures

All Female Male
Number of individuals 1408 589 819
Unadjusted period prevalence (%) 0.34 0.23 0.41
Median age at first event (years) 64.51 63.82 65.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint I9_PERICAOTH and mortality.

Females

Parameter HR [95% CI] p-value
I9_PERICAOTH 2.993 [2.55, 3.52] < 0.001
Birth year 0.993 [0.98, 1.0] 0.111

During the follow-up period (1.1.1998 — 31.12.2019), 982 out of 2768 females with I9_PERICAOTH died.

Males

Parameter HR [95% CI] p-value
I9_PERICAOTH 2.126 [1.82, 2.48] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 1093 out of 3439 males with I9_PERICAOTH died.

Mortality risk

Mortality risk for people of age

years, who have I9_PERICAOTH.

N-year risk Females Males
1 0.357% 0.321%
5 1.841% 2.578%
10 4.339% 6.05%
15 7.882% 11.166%
20 13.798% 19.674%

Relationships between endpoints

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Index endpoint: I9_PERICAOTH – Other diseases of pericardium

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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