cardiovascular disease: A disease involving the cardiovascular system.
Other other unspecified disorders of the circulatory system
DOID EFO Endpoint Browser PheWeb
I9_OTHOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1197 |
4. Check minimum number of eventsNone |
1197 |
5. Include endpointsNone |
1197 |
6. Filter based on genotype QC (FinnGen only) |
1171 |
Control definitions (FinnGen only)
Control exclude
I9_OTH
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Other other unspecified disorders of the circulatory system
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8785 | 4639 | 4036 |
| Only index persons | 6572 | 3616 | 2956 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.13 | 0.11 |
| Only index persons | 0.12 | 0.13 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 62.77 | 62.32 | 63.22 |
| Only index persons | 60.58 | 59.70 | 61.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1171 | 622 | 549 |
| Unadjusted period prevalence (%) | 0.26 | 0.24 | 0.28 |
| Median age at first event (years) | 59.77 | 57.63 | 62.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_OTHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_OTHOTH | 2.025 [1.78, 2.3] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.108 |
During the follow-up period (1.1.1998 — 31.12.2019), 884 out of 2678 females with I9_OTHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_OTHOTH | 1.619 [1.46, 1.8] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 1135 out of 2662 males with I9_OTHOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_OTHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.181% | 0.287% |
| 5 | 1.177% | 1.963% |
| 10 | 2.826% | 5.128% |
| 15 | 5.609% | 9.404% |
| 20 | 9.422% | 15.918% |
Relationships between endpoints
↥Index endpoint: I9_OTHOTH – Other other unspecified disorders of the circulatory system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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