dilated cardiomyopathy: Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
394625 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1962 |
4. Check minimum number of eventsNone |
1962 |
5. Include endpointsNone |
1962 |
6. Filter based on genotype QC (FinnGen only) |
1911 |
Control definitions (FinnGen only)
Control conditions
not I9_IHD
and not I9_HYPERTROCARDMYOP
and not I9_HYPERTROCARDMYOP
Extra metadata
First used in FinnGen datafreeze
DF3
Nonischemic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16110 | 4481 | 11483 |
| Only index persons | 13468 | 3839 | 9629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.13 | 0.32 |
| Only index persons | 0.30 | 0.14 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 59.56 | 62.32 | 58.44 |
| Only index persons | 59.28 | 61.85 | 58.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1911 | 549 | 1362 |
| Unadjusted period prevalence (%) | 0.55 | 0.22 | 0.68 |
| Median age at first event (years) | 58.97 | 58.53 | 59.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_NONISCHCARDMYOP_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_NONISCHCARDMYOP_STRICT | 2.931 [2.56, 3.36] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.147 |
During the follow-up period (1.1.1998 — 31.12.2019), 1023 out of 3592 females with I9_NONISCHCARDMYOP_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_NONISCHCARDMYOP_STRICT | 2.704 [2.44, 2.99] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2926 out of 8846 males with I9_NONISCHCARDMYOP_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have I9_NONISCHCARDMYOP_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.239% | 0.397% |
| 5 | 1.68% | 2.752% |
| 10 | 3.951% | 7.339% |
| 15 | 7.703% | 13.927% |
| 20 | 13.295% | 22.847% |
Relationships between endpoints
↥Index endpoint: I9_NONISCHCARDMYOP_STRICT – Nonischemic cardiomyopathy
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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