brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
244 |
4. Check minimum number of eventsNone |
244 |
5. Include endpointsNone |
244 |
6. Filter based on genotype QC (FinnGen only) |
231 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
I67
Name in latin
Dissectio arteriae cerebralis sine ruptura
Similar endpoints
↥List of similar endpoints to
Dissection of cerebral arteries, nonruptured
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1673 | 729 | 931 |
| Only index persons | 1553 | 683 | 870 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 52.52 | 52.32 | 52.80 |
| Only index persons | 51.96 | 51.56 | 52.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 231 | 121 | 110 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 50.59 | 47.51 | 53.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint I9_DISCER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISCER | 1.628 [1.22, 2.17] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.506 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 624 females with I9_DISCER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISCER | 1.389 [1.11, 1.74] | 0.004 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 787 males with I9_DISCER died.
Mortality risk
Mortality risk for people of age
years, who have I9_DISCER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.298% |
| 5 | 0.878% | 1.694% |
| 10 | 2.544% | 4.33% |
| 15 | 4.874% | 8.115% |
| 20 | 8.809% | 14.239% |
Relationships between endpoints
↥Index endpoint: I9_DISCER – Dissection of cerebral arteries, nonruptured
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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