cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.
Other specified cerebrovascular diseases, other cerebrovascular disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
I9_CEREBDOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2430 |
4. Check minimum number of eventsNone |
2430 |
5. Include endpointsNone |
2430 |
6. Filter based on genotype QC (FinnGen only) |
2331 |
Control definitions (FinnGen only)
Control exclude
I9_CEREBVASC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified cerebrovascular diseases, other cerebrovascular disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases
- Neurological diseases
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 35100 | 17373 | 17089 |
| Only index persons | 20088 | 10110 | 9978 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.50 | 0.48 |
| Only index persons | 0.38 | 0.37 | 0.38 |
| Median age at first event (years) | |||
| Whole population | 72.53 | 75.26 | 69.77 |
| Only index persons | 69.92 | 72.84 | 66.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2331 | 1015 | 1316 |
| Unadjusted period prevalence (%) | 0.55 | 0.40 | 0.66 |
| Median age at first event (years) | 67.03 | 65.74 | 68.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint I9_CEREBDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CEREBDOTH | 1.804 [1.65, 1.98] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 4689 out of 9333 females with I9_CEREBDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CEREBDOTH | 1.745 [1.58, 1.93] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 4617 out of 9686 males with I9_CEREBDOTH died.
Mortality risk
Mortality risk for people of age
years, who have I9_CEREBDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.319% |
| 5 | 0.957% | 1.904% |
| 10 | 2.44% | 4.433% |
| 15 | 4.835% | 8.401% |
| 20 | 8.489% | 14.215% |
Relationships between endpoints
↥Index endpoint: I9_CEREBDOTH – Other specified cerebrovascular diseases, other cerebrovascular disorders in diseases classified elsewhere
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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