No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1365 |
4. Check minimum number of eventsNone |
1365 |
5. Include endpointsNone |
1365 |
6. Filter based on genotype QC (FinnGen only) |
1333 |
Control definitions (FinnGen only)
Control exclude
H8_INNER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H83
Name in latin
Laesio auris internae e strepitu
Similar endpoints
↥List of similar endpoints to
Noise effects on inner ear
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13487 | 861 | 12565 |
| Only index persons | 12716 | 844 | 11872 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.02 | 0.35 |
| Only index persons | 0.43 | 0.03 | 0.45 |
| Median age at first event (years) | |||
| Whole population | 53.71 | 51.05 | 53.80 |
| Only index persons | 52.85 | 51.01 | 52.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1333 | 109 | 1224 |
| Unadjusted period prevalence (%) | 0.57 | 0.04 | 0.61 |
| Median age at first event (years) | 56.42 | 48.42 | 57.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H8_NOISEINNER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_NOISEINNER | 0.93 [0.69, 1.25] | 0.628 |
| Birth year | 0.998 [0.99, 1.01] | 0.64 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 717 females with H8_NOISEINNER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_NOISEINNER | 0.788 [0.72, 0.86] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 1579 out of 10010 males with H8_NOISEINNER died.
Mortality risk
Mortality risk for people of age
years, who have H8_NOISEINNER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.183% |
| 5 | 0.599% | 1.04% |
| 10 | 1.384% | 2.658% |
| 15 | 2.62% | 5.003% |
| 20 | 4.996% | 8.654% |
Relationships between endpoints
↥Index endpoint: H8_NOISEINNER – Noise effects on inner ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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