lens disease: A disease involving the lens of camera-type eye. [database_cross_reference: MONDO:DesignPattern]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
498 |
4. Check minimum number of eventsNone |
498 |
5. Include endpointsNone |
498 |
6. Filter based on genotype QC (FinnGen only) |
484 |
Control definitions (FinnGen only)
Control exclude
H7_LENS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
H27
Name in latin
Dislocatio lentis
Dislocation of lens
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5172 | 2808 | 2333 |
| Only index persons | 4530 | 2530 | 2000 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.07 |
| Only index persons | 0.09 | 0.09 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 75.35 | 79.10 | 70.85 |
| Only index persons | 75.57 | 79.29 | 70.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 484 | 220 | 264 |
| Unadjusted period prevalence (%) | 0.11 | 0.09 | 0.13 |
| Median age at first event (years) | 73.92 | 76.56 | 71.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_LENSDISLOCATIO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LENSDISLOCATIO | 1.052 [0.92, 1.2] | 0.453 |
| Birth year | 0.994 [0.99, 1.0] | 0.142 |
During the follow-up period (1.1.1998 — 31.12.2019), 976 out of 2298 females with H7_LENSDISLOCATIO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_LENSDISLOCATIO | 1.095 [0.92, 1.3] | 0.293 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 1783 males with H7_LENSDISLOCATIO died.
Mortality risk
Mortality risk for people of age
years, who have H7_LENSDISLOCATIO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.085% | 0.2% |
| 5 | 0.743% | 1.17% |
| 10 | 1.606% | 3.076% |
| 15 | 2.894% | 5.677% |
| 20 | 5.148% | 10.003% |
Relationships between endpoints
↥Index endpoint: H7_LENSDISLOCATIO – Dislocation of lens
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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