lens disease: A disease involving the lens of camera-type eye. [database_cross_reference: MONDO:DesignPattern]
Other specified and unspecified disorders of lens
DOID EFO Endpoint Browser PheWeb
H7_DISORDERLENSNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
276 |
4. Check minimum number of eventsNone |
276 |
5. Include endpointsNone |
276 |
6. Filter based on genotype QC (FinnGen only) |
262 |
Control definitions (FinnGen only)
Control exclude
H7_LENS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specified and unspecified disorders of lens
based on the number of shared cases.
Similar with more cases:
- Disorders of lens
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2266 | 1677 | 581 |
| Only index persons | 2126 | 1584 | 542 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 76.62 | 76.97 | 75.56 |
| Only index persons | 76.59 | 76.93 | 75.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 262 | 183 | 79 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 73.92 | 73.40 | 75.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint H7_DISORDERLENSNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.822 [0.71, 0.95] | 0.008 |
| Birth year | 0.991 [0.98, 1.0] | 0.045 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1446 females with H7_DISORDERLENSNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_DISORDERLENSNAS | 0.896 [0.71, 1.13] | 0.349 |
| Birth year | 0.987 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 167 out of 496 males with H7_DISORDERLENSNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_DISORDERLENSNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.164% |
| 5 | 0.401% | 1.067% |
| 10 | 1.029% | 2.606% |
| 15 | 1.935% | 5.137% |
| 20 | 3.429% | 8.56% |
Relationships between endpoints
↥Index endpoint: H7_DISORDERLENSNAS – Other specified and unspecified disorders of lens
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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